plague

Any epidemic disease with a high death rate.

A swarm of insects that attack plants.

“a plague of grasshoppers”

A serious (sometimes fatal) infection of rodents caused by Yersinia pestis and accidentally transmitted to humans by the bite of a flea that has bitten an infected animal.

An annoyance.

“those children are a damn plague”

Any large scale calamity (especially when thought to be sent by God).

Cause to suffer a blight.

Annoy continually or chronically.